Blood Brothers takes the gameplay mechanics of Cabal and transports them to the Wild West, charging a cowboy and Indian team with hunting down outlaw Big Bad John. The core mechanic combines a simplified over-the-shoulder run-and-gun style mechanic with shooting gallery controls – players aim with an on-screen reticle which moves while firing, allowing both character movement and aiming. Additional buttons throw dynamite and perform a rolling dodge to avoid an increasing volley of enemy shots. Though simple, the enjoyable gameplay loop and little touches like the player's end-of-stage victory dance give Blood Brothers an enduring charm.